PRF (Platelet Rich Fibrin)

• PRF is similar to PRP except that PRF naturally contains fibrin for clot scaffolding and localization of mesenchymal stem cells.
•   PRF formation and centrifugation differs from PRP in that there is no anticoagulant and spin times and speeds differ.
•   PRF has implied use as a natural filler.
•   PRF has had remarked success as a complementary component in surgical and nonsurgical
  esthetic treatments.
•   PRF releases platelet-related therapeutic granules for a longer duration and at a slower rate than
  PRP.*Includes: nerve block,  2wks follow-up

PRF (platelet-rich Fibrin) therapy for hair loss is a three-step medical treatment in which a person's blood is drawn, processed, and then injected into the scalp

According to published reports, PRF tends to improve hair caliber and hair growth for about four to six weeks, requiring repeated treatments once a month for 3 months. On average, however, most patients will require their repeat PRF treatment after 6-12 months in order to maintain the hair growth effects

Anyone experiencing hair loss is essentially a good candidate for PRF treatments, but those with early hair loss tend to respond best.

Platelet-rich Fibrin injections may not be appropriate for a patient who:

• Has a medical condition that could worsen or spread with injections, such as an active infection, a metastatic disease, or certain skin diseases. 
• Has certain blood and bleeding disorders

In summary, for those patients who are good candidates and are willing to have surgery, hair transplantation is their best option for the best results. For those unwilling or who are not good candidates for a hair transplant, PRF provides a new and exciting option

Researchers concluded PRF was more effective than minoxidil because patients in the PRF group had earlier and better responses, as well as a significant decrease in short vellus hair, yellow dots and dystrophic hair

• DHT is Dihydrotestosterone (DHT). Itis a steroid hormone stronger than testosterone. The hormone causes body and facial hair to start growing on men and is important for men to reach sexual maturity.

• Later in life, DHT has a negative effect on the hair follicles and causes the hair follicles to shrink. The longer the hair follicle is subjected to DHT, the smaller it gets. At the same time, the hair grows shorter and thinner. DHT also causes the hair to enter the dormant phase quicker, meaning that the hairs grow thinner and shorter and decrease in numbers. These factors together contribute to a noticeable thinning of the hair.

PRF treatment has been proven to be highly effective in stopping the negative effect of DHT on the hair follicle if the treatment begins in time before the hair follicle is completely shrunken.

DHT decreases the size of the hair follicle, which in turn inhibits hair growth. PRF has the opposite effect on the hair follicle. Blood plasma is injected into the scalp and the growth factors in the blood plasma stimulate the stem cells surrounding the hair follicles. The hair follicles expand, and the hair follicle may then produce a stronger hair. Hair growth also increases with PRP.

After 3 treatments, the patient usually only needs to have one PRF treatment every six months to maintain the positive effect of PRF.

However, if you have very high levels of DHT, it’s possible that PRF will not have as great of an effect because the negative effect of DHT cancels out the positive effect of PRF.